Ethanol → HCID 20284570、化合物

反応式

Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:14]([N:15]=1)[C:13](=[O:16])[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=2.[OH-].[Na+].[CH2:19]([OH:21])[CH3:20]>O>[CH2:19]([O:21][C:2]1[CH:3]=[CH:4][C:5]2[N:14]([N:15]=1)[C:13](=[O:16])[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=2)[CH3:20]

参加物

実験手順

To 1.2 g of 2-chloro-10H-pyridazino[3,2-b]quinazolin-10-one dissolved in ethanol, there was added a solution of sodium hydroxide (2.0 g) in water (8 ml), and stirring was continued at 40° C. for 2 hours. After completion of the reaction, the solvent was removed by distillation, followed by addition of an aqueous solution of acetic acid. The precipitates were collected by filtration and recrystallized from a mixture of methanol and water to give 1.0 g of 2-ethoxy-10H-pyridazino[3,2-b]quinazolin-10-one (Compound No. 2). M.P., 159.5°-160.5° C.