Hydrochloric Acid → HCID 21249820、化合物

反応式

COC(=O)C1C=CC=CN=1.[CH3:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([C:30]([OH:32])=[O:31])=[N:17][C:18]=1[O:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=1.[OH-].[Na+].Cl>C(O)C>[CH3:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([C:30]([OH:32])=[O:31])=[N:17][C:18]=1[O:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:28])([F:29])[F:27])[CH:21]=1

参加物

反応条件

温度: 70 °C

実験手順

5-methoxy-6-[3-(trifluoromethyl)phenoxy] picolinic acid picolinic acid methyl ester (0.7 g, 0.0021 mol) was dissolved in 2.8 ml of ethyl alcohol. One milliliter of an aqueous solution of sodium hydroxide (0.102 g, 0.0021×1.2 mol) was added to the obtained solution. The resultant mixture was heated and stirred at 70° C. for 1.5 hours. After cooling, the obtained reaction solution was mixed with 2 ml of concentrated hydrochloric acid, thereby precipitating solids. The precipitated solids were filtered out from the solution, washed with water and then dried.