p-Toluenesulfonic acid → Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate
反応式
[CH3:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[C:17]([F:23])[C:3]=1[C:4]([CH:6](C(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[CH3:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[C:17]([F:23])[C:3]=1[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]参加物
4
実験手順
To diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate (5.1 g) are added water (20 ml) and p-toluenesulfonic acid (30 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.3 g).
後処理
- temperaturethe mixture is refluxed for 2.5 hours
- temperatureAfter cooling
- extractionthe resultant is extracted with diethyl ether
- dry with materialthe extract is dried over magnesium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-2da68ab0871c4a05aa3d4f9224f8df1c
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723648
反応ノート
読み込み中…