3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole → HCID 11312687、化合物

HRID 1275714ノート

反応式

HRID 1275714 の反応式
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[O:18][C:19]([CH2:22][OH:23])=[CH:20][CH:21]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(Cl)(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[O:18][C:19]([CH:22]=[O:23])=[CH:20][CH:21]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 57123-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole

生成物 1

HCID 11312687HCID 11312687、化合物

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

7.7 g (25.3 mmol) of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole and 11 g (126.5 mmol) of activated manganese(IV) oxide in 200 ml of dry carbon tetrachloride were stirred under reflux for 4.5 h. For work-up, the mixture was filtered off with suction and the filtrate was washed with water, dried and concentrated using a rotary evaporator. The crude product was recrystallized from isopropanol. This gave 4.8 g (63%) of the title compound. m.p.: 108° C.

後処理

  1. temperatureunder reflux for 4.5 h
  2. filtrationFor work-up, the mixture was filtered off with suction
  3. washthe filtrate was washed with water
  4. customdried
  5. concentrationconcentrated
  6. customa rotary evaporator
  7. customThe crude product was recrystallized from isopropanol

出典と根拠

ORDレコード
ord-e9b5cab4f8fe4c76978e9b6f07b7284d
出典データセット
uspto-grants-2000_12
特許番号
US06162819

反応ノート

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