3-Chloro-2-[4-(1-methylethylamino)-3-nitrophenyl]-5-trifluoromethylpyridine → 2-[3-Amino-4-(1-methylethylamino)phenyl]-3-chloro-5-trifluoromethylpyridine
反応式
ClC1C(C2C=CC(O)=C(N)C=2)=NC=C(C(F)(F)F)C=1.[Cl:20][C:21]1[C:22]([C:31]2[CH:36]=[CH:35][C:34]([NH:37][CH:38]([CH3:40])[CH3:39])=[C:33]([N+:41]([O-])=O)[CH:32]=2)=[N:23][CH:24]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:26]=1>[Fe]>[NH2:41][C:33]1[CH:32]=[C:31]([C:22]2[C:21]([Cl:20])=[CH:26][C:25]([C:27]([F:30])([F:29])[F:28])=[CH:24][N:23]=2)[CH:36]=[CH:35][C:34]=1[NH:37][CH:38]([CH3:40])[CH3:39]参加物
4
実験手順
In a similar manner to the preparation of 3-chloro-2-(3-amino-4-hydroxyphenyl)-5-trifluoromethylpyridine described above, 46.1 g of 3-chloro-2-[4-(1-methylethylamino)-3-nitro-phenyl]-5-trifluoromethylpyridine and 21.5 g of iron powder gave 39.1 g (93%) of colorless crystals; m.p.: 116-117° C.