Hydrazine hydrate (1:1) → 5-Bromo-1-naphthohydrazide

HRID 1276286

反応式

HRID 1276286 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]([O:14]C)=O.O.[NH2:17][NH2:18]>CO>[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]([NH:17][NH2:18])=[O:14]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 4557673Methyl 5-bromo-1-naphthoate

生成物 1

HCID 221158865-Bromo-1-naphthohydrazide収率 65.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl 5-bromo-1-naphthoate (D1) (5.32 g, 20 mmol) and hydrazine hydrate (5.7 ml, 100 mmol) were stirred at reflux in methanol (50 ml) for 48 h. After cooling, the solid was filtered off, washed with cold methanol, and dried in vacuo at 60° C., yielding the title compound (3.48 g, 65%) as a grey-brown crystalline powder.

後処理

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. washwashed with cold methanol
  4. customdried in vacuo at 60° C.

出典と根拠

ORDレコード
ord-df9142386daf43d2804491a3bbe60fda
出典データセット
uspto-grants-2000_12
特許番号
US06166034

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