Pyridine → L-Tryptophanamide

HRID 1276591ノート

反応式

HRID 1276591 の反応式
Cl.CO[C:4](=[O:17])[C@H:5]([CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)[NH2:6].[N:18]1C=CC=CC=1>ClCCl>[NH2:6][C@H:5]([C:4]([NH2:18])=[O:17])[CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1

参加物

4

反応物 2

HCID 1049PyridineHCID 2734891Methyl tryptophanate hydrochloride

生成物 1

HCID 439356L-Tryptophanamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of the active ester VIII (0.035 g, 0.06 mmol), L-tryptophan methyl ester hydrochloride (0.049 g, 0.19 mmol) and pyridine (0.015 g, 0.19 mmol) in dichloromethane (20 ml) was stirred overnight. The solvent was removed under reduced pressure and the residue purified by column chromatography (ethyl acetate elution) to yield the trytophan amide as a dark red crystalline solid.

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue purified by column chromatography (ethyl acetate elution)

出典と根拠

ORDレコード
ord-1b4fd1c1137a43baa4c47018ac7cf7d7
出典データセット
uspto-grants-2000_12
特許番号
US06166202

反応ノート

読み込み中…