Methanol → 1,1-Dimethoxy-cyclopentane

HRID 1276841

反応式

HRID 1276841 の反応式
[C:1]1(=[O:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:7][O:8][Na].[CH3:10]O>>[CH3:10][O:6][C:1]1([O:8][CH3:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 3

HCID 887MethanolHCID 8452CyclopentanoneHCID 178418582HCID 178418582、化合物

生成物 1

HCID 5230521,1-Dimethoxy-cyclopentane収率 60%

実験手順

Cyclopentanone (25 g, 0.3 mol) was added at room temperature to a solution of trimethyl ortoformate (33 ml, 0.3 mol) in 60 ml anhydrous MeOH containing 75 mg TsOH. The resulting mixture was allowed to stand at room temperature for 2 hours. After adding MeONa to pH 8-8.5 and removing the MeOH, the remaining portion was distilled in vacuo to give 23.2 g (60%) of pure cyclopentanone dimethyl acetal having a boiling point of 42° C. (8 torr). NMR-1H (δ, ppm) in CDCI3 : 1.43-1.72 m (8H, 4CH2); 3.08 s (6H, 2 OCH3). NMR-13C (6 ppm) in CDCl3 : 22.89 (2CH 2), 33.82 (2CH2), 48.76 (2CH3O), 111.81 (O--C--O).

後処理

  1. customremoving the MeOH
  2. distillationthe remaining portion was distilled in vacuo

出典と根拠

ORDレコード
ord-3b7f2eb4be304eb98486efeaf9b8bb28
出典データセット
uspto-grants-2000_12
特許番号
US06166260

関連ノート

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