Sodium Carbonate → 3-Isoxazolamine, 5-(1,1-dimethylethyl)-

HRID 127715

反応式

HRID 127715 の反応式
[C:1]([CH2:7][C:8]#[N:9])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].C(=O)([O-])[O-].[Na+].[Na+].S(O)(O)(=O)=O.[NH2:21]O>O>[NH2:9][C:8]1[CH:7]=[C:1]([C:2]([CH3:5])([CH3:4])[CH3:3])[O:6][N:21]=1

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-HCID 159255Hydroxylamine, sulfate (1:1)

生成物 1

HCID 1714733-Isoxazolamine, 5-(1,1-dimethylethyl)-収率 124.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A suspension of pivaloylacetonitrile (12.52 g), sodium carbonate (8.74 g) and water (200 ml) is stirred and mixed with hydroxylamine sulfate (9.03 g) at 25° C. pH 7.11. The reaction mixture is treated as in Example 2 to give 3-amino-5-t-butylisoxazole (12.01 g). Yield, 85.7%. Purity, 95.8%.

後処理

  1. additionThe reaction mixture is treated as in Example 2

出典と根拠

ORDレコード
ord-fb681df70af54e46886ea03fbdfbd7f2
出典データセット
uspto-grants-1981_03
特許番号
US04256899

関連ノート

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