Triethylamine → N-cycloheptyl-N-methylamine

In 1,2-dichloroethane (50 ml) were suspended cyclo-heptanone (2 g), methylamine hydrochloride (3 g) and triethylamine (6.2 ml), and to the suspension was added sodium triacetoxy boron hydride (5.3 g) under ice-cooling. Under nitrogen atmosphere, the mixture was stirred at room temperature over night. The solvent was evaporated, and the residue was neutralized with sodium hydroxide. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution and dried with anhydrous magnesium sulfate. Under reduced pressure, the solvent was evaporated to give N-methylcycloheptylamine (1.8 g) as colorless oil.

1. temperaturecooling
2. customThe solvent was evaporated
3. extractionThe mixture was extracted with ethyl acetate
4. washThe organic layer was washed with saturated sodium chloride solution
5. dry with materialdried with anhydrous magnesium sulfate
6. customUnder reduced pressure, the solvent was evaporated

ORDレコード

ord-66add22207e5487ebf571719aa946b99

出典データセット

uspto-grants-2000_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06166006