Triethylamine → 3-Isoxazolamine, 5-(1,1-dimethylethyl)-

HRID 127716

反応式

HRID 127716 の反応式
[C:1]([CH2:7][C:8]#[N:9])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].C([N:12](CC)CC)C.S(O)(O)(=O)=O.NO>O>[NH2:9][C:8]1[CH:7]=[C:1]([C:2]([CH3:5])([CH3:4])[CH3:3])[O:6][N:12]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-HCID 159255Hydroxylamine, sulfate (1:1)

生成物 1

HCID 1714733-Isoxazolamine, 5-(1,1-dimethylethyl)-収率 81.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A suspension of pivaloylacetonitrile (12.52 g) and triethylamine (11.27 g) in water (200 ml) is stirred and mixed with hydroxylamine sulfate (9.03 g). pH 8.22. The reaction mixture is treated as in Example 2 to give 3-amino-5-t-butylisoxazole (11.45 g; yield, 81.7%).

後処理

  1. additionThe reaction mixture is treated as in Example 2

出典と根拠

ORDレコード
ord-d73c023895844ceaa0b5ec960b928bde
出典データセット
uspto-grants-1981_03
特許番号
US04256899

関連ノート

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