Hydrochloric Acid → Ethyl 7-bromo-1-formyl-2,3-dihydro-1-benzazepine-4-carboxylate

In t-butanol (500 ml) were dissolved ethyl 4-(4-bromo-2,N-diformylanilino)butyrate (15.32 g) and potassium t-butoxide (5.53 g), and the mixture was ref luxed for 30 minutes. To the mixture were added water (500 ml) and 1N hydrochloric acid (50 ml), and the mixture was extracted with ethyl acetate (1000 ml). Theorganiclayerwaswashedwithsaturatedbrine (200 ml) and dried with magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified with silica gel column chromatography (300 g, hexane:ethyl acetate=4:1→1:1) to give ethyl 7-bromo-1-formyl-2,3-dihydro-1-benzazepine-4-carboxylate (3.13 g, 22%) and 7-bromo-1-formyl-2,3-dihydro-1-benzazepine-4-carboxylic acid (1.39 g, 10%).

1. extractionthe mixture was extracted with ethyl acetate (1000 ml)
2. dry with materialTheorganiclayerwaswashedwithsaturatedbrine (200 ml) and dried with magnesium sulfate
3. customThe solvent was evaporated under reduced pressure
4. customthe residue was purified with silica gel column chromatography (300 g, hexane:ethyl acetate=4:1→1:1)

ORDレコード

ord-736d4569bdeb4b27a0646c1e45fe27f9

出典データセット

uspto-grants-2000_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06166006