Hexylamine → N-hexyl-2-iodobenzamide

HRID 1277907

反応式

HRID 1277907 の反応式
[CH2:1]([NH2:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[I:8][C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11](Cl)=[O:12]>O1CCCC1>[CH2:1]([NH:7][C:11](=[O:12])[C:10]1[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=1[I:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

参加物

4

反応物 2

HCID 8102HexylamineHCID 691122-Iodobenzoyl chloride

生成物 1

HCID 615638N-hexyl-2-iodobenzamide収率 76.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Solutions of 12.2 g hexylamine and 8.0 g o-iodobenzoyl chloride in a total of 20 ml tetrahydrofuran were reacted for 10 minutes. The tetrahydrofuran was removed by heating on a water bath at 65° for 10 minutes and 50 ml of water were added to precipitate the crude product. The precipitate was recovered as in Example 1 and recrystallized from a benzene/hexane mixture as white crystals, to yield 7.6 g of N-hexyl-o-iodobenzamide, m.p. 104°-105°, Rf 0.78.

後処理

  1. customThe tetrahydrofuran was removed
  2. temperatureby heating on a water bath at 65° for 10 minutes
  3. addition50 ml of water were added
  4. customto precipitate the crude product
  5. customThe precipitate was recovered as in Example 1
  6. customrecrystallized from a benzene/hexane mixture as white crystals

出典と根拠

ORDレコード
ord-f587de205fb14fe18c0c8de2e5dbd414
出典データセット
uspto-grants-1981_07
特許番号
US04279887

関連ノート

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