Octadecylamine → N-octadecyl-o-iodobenzamide

HRID 1277909

反応式

HRID 1277909 の反応式
[CH2:1]([NH2:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[I:20][C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23](Cl)=[O:24].Cl.C(N)CCCCCCCCCCCCCCCCC>CCOCC.C(O)C>[CH2:1]([NH:19][C:23](=[O:24])[C:22]1[CH:26]=[CH:27][CH:28]=[CH:29][C:21]=1[I:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

参加物

6

反応物 3

HCID 15793OctadecylamineHCID 691122-Iodobenzoyl chlorideHCID 519552Stearamine hydrochloride

生成物 1

HCID 13020107N-octadecyl-o-iodobenzamide収率 8%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of 17.9 g of octadecylamine in a mixture of 300 ml of ether and 10 ml of ethanol was reacted with a solution of 8.0 g of o-iodobenzoyl chloride in 25 ml of ether for 10 minutes. The precipitate which formed contained octadecylamine hydrochloride. This precipitate was recovered and discarded. The volume was thereafter reduced to approximately half at 65° on a water bath. The resulting precipitate was recovered in accordance with the procedure of Example 3. The crude product was recrystallized from benzene to yield 1.2 g of N-octadecyl-o-iodobenzamide as a white microcrystalline solid, m.p. 94°-96°, Rf 0.77.

後処理

  1. customThe precipitate which formed
  2. customThis precipitate was recovered
  3. customThe volume was thereafter reduced to approximately half at 65° on a water bath
  4. customThe resulting precipitate was recovered in accordance with the procedure of Example 3
  5. customThe crude product was recrystallized from benzene

出典と根拠

ORDレコード
ord-47dc18bce46f4196a740298cca09af88
出典データセット
uspto-grants-1981_07
特許番号
US04279887

関連ノート

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