Hydrochloric Acid → HCID 45263932、化合物

HRID 1277955ノート

反応式

HRID 1277955 の反応式
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH:12]=[C:13]([C:15]([O:17]CC)=[O:16])[N:14]=[C:4]2[CH:3]=1.[OH-].[Na+].Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH:12]=[C:13]([C:15]([OH:17])=[O:16])[N:14]=[C:4]2[CH:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12763962HCID 12763962、化合物

生成物 1

HCID 45263932HCID 45263932、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

820 mg of ethyl 5-chloroimidazo-[1,2-a]-quinoline-2-carboxylate were dissolved in 50 ml of ethanol and 6.6 ml of 0.5 N sodium hydroxide solution were added to the solution obtained. The resultant mixture was refluxed for 1 hour, then was cooled to room temperature and acidified to a pH of ~1 by addition of concentrated hydrochloric acid. The solvent was removed under vacuum and the residue was dissolved in methanol. The solution formed was filtered and the filtrate was reduced in volume under vacuum and then was cooled to obtain off-white crystals of 5-chloroimidazo-[1,2-a]-quinoline-2-carboxylic acid hydrochloride melting at 263°-265° C. (decomposition).

後処理

  1. customobtained
  2. customThe solvent was removed under vacuum
  3. dissolutionthe residue was dissolved in methanol
  4. customThe solution formed
  5. filtrationwas filtered
  6. temperaturewas cooled

出典と根拠

ORDレコード
ord-7ea61fb106854c19a8506925ad73ed4f
出典データセット
uspto-grants-1981_07
特許番号
US04279912

反応ノート

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