Sodium Hydroxide → HCID 70569092、化合物

HRID 1277973ノート

反応式

HRID 1277973 の反応式
[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]1[N:7]2[CH:12]=[C:13]([C:15]([O:17]CC)=[O:16])[N:14]=1.[OH-].[Na+]>C(O)C.O>[OH2:16].[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]1[N:7]2[CH:12]=[C:13]([C:15]([OH:17])=[O:16])[N:14]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 12763984HCID 12763984、化合物

生成物 1

HCID 70569092HCID 70569092、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

100 mg of ethyl 6-chloroimidazo-[1,2-a]-quinoline-2-carboxylate were suspended in a mixture of 4.5 ml of ethanol and 2 ml of water and then 0.5 ml of N sodium hydroxide solution was added. The mixture was heated on a steam bath for 4 hours and the resulting solution was filtered then acidified with 0.5 ml of N hydrochloric acid and cooled to give colorless crystals of 6-chloroimidazo-[1,2-a]-quinoline-2-carboxylic acid monohydrate melting at 288°-289° C.

後処理

  1. temperatureThe mixture was heated on a steam bath for 4 hours
  2. filtrationthe resulting solution was filtered
  3. temperaturecooled

出典と根拠

ORDレコード
ord-107e2c23e3bd4fd2a21fe442052e7545
出典データセット
uspto-grants-1981_07
特許番号
US04279912

反応ノート

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