Sodium Hydroxide → HCID 70571317、化合物
反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([Cl:20])=[CH:7][C:8]3[N:9]2[CH:12]=[C:13]([C:15]([O:17]CC)=[O:16])[N:14]=3)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[OH2:16].[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([Cl:20])=[CH:7][C:8]3[N:9]2[CH:12]=[C:13]([C:15]([OH:17])=[O:16])[N:14]=3)=[CH:4][CH:3]=1参加物
4
実験手順
400 mg of ethyl 8-bromo-5-chloroimidazo-[1,2-a]-quinoline-2-carboxylate were suspended in 200 ml of 50% aqueous ethanol and 4 ml of N sodium hydroxide solution were added. The mixture was heated on a steam bath for 1 hour and the resulting solution was filtered, then acidified with 4.4 ml of N hydrochloric acid. The mixture was cooled in ice to obtain cream needles of 8-bromo-5-chloroimidazo-[1,2-a]-quinoline-2-carboxylic acid monohydrate melting at >300° C.