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4-Chlorobenzyl cyanide → 2-(alpha-Cyano-4-chlorobenzylidene)-1-methylpyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorobenzyl cyanide | HCID 241582 | — |
| 反応物 | 2,2-Diethoxy-1-methylpyrrolidine | HCID 297308 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 2-(alpha-Cyano-4-chlorobenzylidene)-1-methylpyrrolidine | HCID 53867175 | — |
反応手順
Boil 22.7 g of 2,2-diethoxy-1-methylpyrrolidine, 19.8 g of 4-chlorobenzylcyanide and 90 ml of benzene for 1 hour under reflux and with stirring. Distil off the volatile constituents under a vacuum. After trituration with a little diethyl ether, filter off the residue to obtain 20.8 g (68% of theory) and the title compound (m.p. 71° to 72° from isopropanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04279918 |
| 出典データセット | uspto-grants-1981_07 |
| ORD ID | ord-38d157ccb44247ad82d5a58cc7c67f0b |
| 出典メモ | uspto-grants-1981_07 |