Sodium borohydride → HCID 21163070、化合物

HRID 1278211ノート

反応式

HRID 1278211 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([CH:16]=[O:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.[BH4-].[Na+]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([CH2:16][OH:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 21163078HCID 21163078、化合物

生成物 1

HCID 21163070HCID 21163070、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 2.0 g. of 7-(3-pyridyl)pyrazolo[1,5-a]-pyrimidine-3-carboxaldehyde and 0.35 g. of sodium borohydride in 100 ml. of methanol is stirred for 16 hours. The mixture is concentrated to dryness in vacuo and dichloromethane is added. The solution is washed with saturated sodium bicarbonate and passed through a column of hydrous magnesium silicate. The eluent is concentrated and diluted with hexane to give the product of the example.

後処理

  1. additionA mixture of 2.0 g
  2. concentrationThe mixture is concentrated to dryness in vacuo and dichloromethane
  3. additionis added
  4. washThe solution is washed with saturated sodium bicarbonate
  5. concentrationThe eluent is concentrated
  6. additiondiluted with hexane
  7. customto give the product of the example

出典と根拠

ORDレコード
ord-d8dab2706e6a4c42ad1893aae81e8fd3
出典データセット
uspto-grants-1981_07
特許番号
US04281000

反応ノート

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