N-bromobutanimide → HCID 12766251、化合物

HRID 1278214ノート

反応式

HRID 1278214 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][CH:15]=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.[Br:16]N1C(=O)CCC1=O>ClCCl>[Br:16][C:15]1[CH:14]=[N:13][N:12]2[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[CH:8][CH:9]=[N:10][C:11]=12

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 11206374HCID 11206374、化合物

生成物 1

HCID 12766251HCID 12766251、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 1.96 g. of 7-(3-pyridyl)pyrazolo[1,5-a]-pyrimidine and 1.97 g. of N-bromosuccinimide in 100 ml. of dichloromethane is heated on a steam bath for 15 minutes. The mixture is poured into ice cold 2.5 N sodium hydroxide. The organic layer is separated and dried then is passed through a column of hydrous magnesium silicate. The column is washed with dichloromethane and the eluent is concentrated and diluted with hexane to give 1.8 g. of the product of the example, m.p. 243°-244° C.

後処理

  1. additionA mixture of 1.96 g
  2. customThe organic layer is separated
  3. customdried
  4. washThe column is washed with dichloromethane
  5. concentrationthe eluent is concentrated
  6. additiondiluted with hexane
  7. customto give 1.8 g

出典と根拠

ORDレコード
ord-4c3bbabffed84782b30cb09ae69a4eaf
出典データセット
uspto-grants-1981_07
特許番号
US04281000

反応ノート

読み込み中…