Hydrochloric Acid → HCID 12766252、化合物

HRID 1278231ノート

反応式

HRID 1278231 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]([O:18]CC)=[O:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.[OH-].[Na+].N1C=CC=C(C2N3N=CC(C([O-])=O)=C3N=CC=2)C=1.[Na+].Cl>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]([OH:18])=[O:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11196438ETHYL 7-(PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLATEHCID 23720712HCID 23720712、化合物

生成物 1

HCID 12766252HCID 12766252、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 6.0 g. of ethyl 7-(3-pyridyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate, 125 ml. of ethanol and 50 ml. of 1 N sodium hydroxide is heated on a steam bath for 4 hours. The mixture is chilled and filtered to give 5.85 g. of sodium 7-(3-pyridyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate, m.p. 360°-363° C. dec. The preceding compound is stirred with 1 N hydrochloric acid and the mixture is filtered to give 5.0 g. of the product of the example, m.p. 286°-287° C. dec. (gas evolution).

後処理

  1. additionA mixture of 6.0 g
  2. temperatureThe mixture is chilled
  3. filtrationfiltered
  4. customto give 5.85 g
  5. filtrationthe mixture is filtered
  6. customto give 5.0 g

出典と根拠

ORDレコード
ord-81dfaa597326443b8fade9b1a63cc380
出典データセット
uspto-grants-1981_07
特許番号
US04281000

反応ノート

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