Sodium Hydroxide → 4,4'-((4-((3-(4-Morpholinyl)propyl)thio)-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine

HRID 1278338ノート

反応式

HRID 1278338 の反応式
CC1C=CC(S(O)(=O)=O)=CC=1.CC1C=CC(S(O)(=O)=O)=CC=1.Cl[C:24]1[CH:29]=[CH:28][C:27]([S:30]([CH2:33][CH2:34][CH2:35][N:36]2[CH2:41][CH2:40][O:39][CH2:38][CH2:37]2)(=[O:32])=[O:31])=[CH:26][C:25]=1[S:42]([CH2:45][CH2:46][CH2:47][N:48]1[CH2:53][CH2:52][O:51][CH2:50][CH2:49]1)(=[O:44])=[O:43].Cl.[N:55]1([CH2:61][CH2:62][CH2:63][S:64]C(=N)N)[CH2:60][CH2:59][O:58][CH2:57][CH2:56]1.[OH-].[Na+]>O>[N:55]1([CH2:61][CH2:62][CH2:63][S:64][C:24]2[CH:29]=[CH:28][C:27]([S:30]([CH2:33][CH2:34][CH2:35][N:36]3[CH2:41][CH2:40][O:39][CH2:38][CH2:37]3)(=[O:32])=[O:31])=[CH:26][C:25]=2[S:42]([CH2:45][CH2:46][CH2:47][N:48]2[CH2:53][CH2:52][O:51][CH2:50][CH2:49]2)(=[O:44])=[O:43])[CH2:60][CH2:59][O:58][CH2:57][CH2:56]1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 21163758HCID 21163758、化合物HCID 21163760HCID 21163760、化合物

生成物 1

HCID 211637644,4'-((4-((3-(4-Morpholinyl)propyl)thio)-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 5.0 g (0.0060 mole) of 4,4'-((4-chloro-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine bis(4-methylbenzenesulfonate), 1.4 g (0.0060 mole) of S-(3-(4-morpholinyl)propyl)isothiourea hydrochloride and 0.8 g (0.02 mole) of sodium hydroxide in 80 ml of water was heated under reflux with stirring for 3.5 hours, cooled and extracted with methylene chloride. The extract was dried over anhydrous sodium sulfate, and the solvent was removed by evaporation, leaving the product as 4,4'-((4-((3-(4-morpholinyl)propyl)thio)-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine a yellow, viscous oil.

後処理

  1. temperatureunder reflux
  2. temperaturecooled
  3. extractionextracted with methylene chloride
  4. dry with materialThe extract was dried over anhydrous sodium sulfate
  5. customthe solvent was removed by evaporation

出典と根拠

ORDレコード
ord-b4f67c3d4be24bf081206a6bc760a44c
出典データセット
uspto-grants-1981_07
特許番号
US04281118

反応ノート

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