Ethanolamine → 4-Fluoro-N-(2-hydroxyethyl)benzenesulfonamide

反応式

[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH2:12]([CH2:14][NH2:15])[OH:13]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:15][CH2:14][CH2:12][OH:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1

参加物

反応物 2

HCID 700Ethanolamine

HCID 95884-Fluorobenzenesulfonyl chloride

生成物 1

HCID 15876834-Fluoro-N-(2-hydroxyethyl)benzenesulfonamide

実験手順

The title compound was prepared according to the procedure of Intermediate 33 from 3.97 g (20 mmol) of 4-fluorobenzenesulfonyl chloride and 3.11 g (50 mmol) of ethanolamine, yielding 3.0 g of a white solid; m.p. 77-78° C.; MS (ES) m/z 219.8 (MH+); HRMS (EI) Calcd. for C8H10FNO3S (M+): 219.0366, Found: 219.0369.

出典と根拠

ORDレコード: ord-ac12dfeaa76f4340b608541a144041c5
出典データセット: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06444685B1

反応ノート

読み込み中…