p-Toluenesulfonic acid → HCID 54413865、化合物

反応式

[C:1]([NH:14][C@H:15]([C:17]([OH:19])=[O:18])[CH3:16])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[CH2:20]([CH:28]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH2:29]O)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].C1(C)C=CC(S(O)(=O)=O)=CC=1.C(=O)([O-])O.[Na+]>>[CH2:20]([CH:28]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH2:29][O:18][C:17](=[O:19])[C@H:15]([CH3:16])[NH:14][C:1](=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

参加物

反応物 4

HCID 6101p-Toluenesulfonic acid

HCID 214142-Octyldodecanol

HCID 516892Sodium Bicarbonate

HCID 13854541N-LAUROYL-L-ALANINE

生成物 1

HCID 54413865HCID 54413865、化合物収率 91.1%

反応条件

温度: 130 °C

実験手順

N-Lauroylalanine (10 g) and 9.5 g of 2-octyldodecanol were charged in a 200-ml flask, and thereto was added 0.5 g of p-toluenesulfonic acid as the catalyst. The mixture was maintained at 130° C. for 3 hours for reaction. To the reaction mixture was added about 200 ml of a aqueous saturated solution of sodium hydrogen carbonate, and the resulting aqueous layer was removed. The oily layer was further washed with water. The extracted oily layer was well dried by adding 5 g of anhydrous magnesium sulfate thereto, and the magnesium sulfate was then filtered off to give 16 g (yield: 82%) of a liquid product.