Sulfuric Acid → 7-Chloro-4-methyl-8-nitroisoquinoline

HRID 127920

反応式

HRID 127920 の反応式
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[N+:18]([O-])([O-:20])=[O:19].[K+]>>[Cl:1][C:2]1[C:11]([N+:18]([O-:20])=[O:19])=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 1118Sulfuric Acid2 回HCID 24434Potassium NitrateHCID 205232237-Chloro-4-methylisoquinoline

生成物 1

HCID 205232187-Chloro-4-methyl-8-nitroisoquinoline

実験手順

A mixture of 17.7 g. (0.1 mole) of 7-chloro-4-methylisoquinoline and 100 ml. of concentrated sulfuric acid is treated with 10 g. (0.1 mole) of potassium nitrate dissolved in 150 ml. of concentrated sulfuric acid. The mixture is stirred for one hour, quenched on ice, made alkaline with ammonium hydroxide and filtered to yield 7-chloro-4-methyl-8-nitroisoquinoline.

後処理

  1. additionA mixture of 17.7 g
  2. customquenched on ice
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-a885dba6cb6a4d0f9161773f58b06d57
出典データセット
uspto-grants-1981_03
特許番号
US04258049

関連ノート

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