4-Toluenesulfonyl chloride → HCID 20523222、化合物

HRID 127922ノート

反応式

HRID 127922 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[CH:6]([NH:8][CH2:9][CH:10]([O:13][CH3:14])[O:11][CH3:12])[CH3:7].[S:18](Cl)([C:21]1[CH:27]=[CH:26][C:24]([CH3:25])=[CH:23][CH:22]=1)(=[O:20])=[O:19]>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[CH:6]([N:8]([CH2:9][CH:10]([O:11][CH3:12])[O:13][CH3:14])[S:18]([C:21]1[CH:27]=[CH:26][C:24]([CH3:25])=[CH:23][CH:22]=1)(=[O:20])=[O:19])[CH3:7]

参加物

4

反応物 2

HCID 73974-Toluenesulfonyl chlorideHCID 20523216HCID 20523216、化合物

生成物 1

HCID 20523222HCID 20523222、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒2 回

反応条件

温度
25 °C

実験手順

A mixture of 23.9 g. (0.1 mole) of 3-methoxy-α-methyl-N-(2,2-dimethoxyethyl)benzylamine in 100 ml. of dry pyridine is stirred, cooled and treated with a solution of 20.2 g. (0.107 mole) of tosyl chloride in 100 ml. of dry pyridine. The mixture is stirred at 25° C. for three days, poured into 800 ml. of water and extracted with ether. The combined ether extracts are washed with dilute hydrochloric acid and then with water, dried, filtered and evaporated to yield 3-methoxy-α-methyl-N-(2,2-dimethoxyethyl)-N-tosyl-benzylamine.

後処理

  1. additionA mixture of 23.9 g
  2. temperaturecooled
  3. additiontreated with a solution of 20.2 g
  4. additionpoured into 800 ml
  5. extractionof water and extracted with ether
  6. washThe combined ether extracts are washed with dilute hydrochloric acid
  7. dry with materialwith water, dried
  8. filtrationfiltered
  9. customevaporated

出典と根拠

ORDレコード
ord-30188f972d4547309a1758fa2af52d56
出典データセット
uspto-grants-1981_03
特許番号
US04258049

反応ノート

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