反応式
[OH:1][CH2:2][C:3]1[O:4][C:5](C)=[CH:6][C:7](=[O:17])[C:8]=1[O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.OCC1OC=CC(=O)C=1O.C(Br)C1C=CC=CC=1>>[OH:1][CH2:2][C:3]1[O:4][CH:5]=[CH:6][C:7](=[O:17])[C:8]=1[O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
4
実験手順
The title compound was prepared by the method outlined for 2-hydroxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one, using 7.1 g (50 mmol, 1 eq.) of 2-hydroxymethyl-3-hydroxy-pyran-4(1H)-one and 9.5 g benzyl bromide (55 mmol 1.1 eq.) to yield the crude product as an organic oil. Further purification by column chromatography on silica gel (eluant: 10% CH3OH/90% CHCl3) furnished the pure product (9.4 g, 81%) as a bright yellow oil. (Looker and Clifton (1986).
後処理
- customto yield the crude product as an organic oil
出典と根拠
- ORDレコード
- ord-c5411fcb1f6449b9840dc8e9cd8ae1f1
- 出典データセット
- uspto-grants-2002_09
- 特許番号
- US06448273B1
関連ノート
読み込み中…