Isopropanol → 1-n-Propyl-1-phenyl-2-(3-sulfamoyl-4 chlorobenzoyl) hydrazine

HRID 127959

反応式

HRID 127959 の反応式
[C:1]1([N:7]([CH2:9][CH2:10][CH3:11])[NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)(O)[O-].[Na+].C(O)(C)C.[S:21]([C:25]1[CH:26]=[C:27]([CH:31]=[CH:32][C:33]=1[Cl:34])[C:28](Cl)=[O:29])(=[O:24])(=[O:23])[NH2:22]>O>[CH2:9]([N:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[NH:8][C:28](=[O:29])[C:27]1[CH:31]=[CH:32][C:33]([Cl:34])=[C:25]([S:21](=[O:23])(=[O:24])[NH2:22])[CH:26]=1)[CH2:10][CH3:11]

参加物

6

反応物 4

HCID 3776IsopropanolHCID 516892Sodium BicarbonateHCID 30179793-(Aminosulfonyl)-4-chlorobenzoyl chlorideHCID 123271621-Phenyl-1-propylhydrazine

生成物 1

HCID 155714991-n-Propyl-1-phenyl-2-(3-sulfamoyl-4 chlorobenzoyl) hydrazine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A vigorously stirred mixture of 14.0 g (0.1 mol) 1-phenyl-1-n-propylhydrazine, 8.4 g (0.1 mol) sodium bicarbonate, and 100 ml isopropanol was chilled to 0°-5° C., 23 g (0.09 mol) 3-sulfamoyl-4-chlorobenzoyl chloride was added in one portion, and the reaction mixture was allowed to stir for several hours, gradually warming to room temperature. Dilution with water and refrigeration overnight yielded solid material which was collected and recrystallized from acetone/water, mp. 102° C. (d).

後処理

  1. temperaturewas chilled to 0°-5° C.
  2. customwas collected
  3. customrecrystallized from acetone/water, mp. 102° C. (d)

出典と根拠

ORDレコード
ord-5ad3a84d3190480f938908c1fad147db
出典データセット
uspto-grants-1981_03
特許番号
US04258059

関連ノート

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