Trifluoroacetic acid → HCID 59909816、化合物

HRID 1279855ノート

反応式

HRID 1279855 の反応式
[Cl:1][C:2]1[CH:32]=[CH:31][C:5]([O:6][CH2:7][C:8]2[N:12]=[C:11]([C@H:13]([CH2:22][CH2:23][CH2:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])[O:10][N:9]=2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]2[N:12]=[C:11]([C@H:13]([CH2:22][CH2:23][CH2:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:14][C:15]([OH:17])=[O:16])[O:10][N:9]=2)=[CH:31][CH:32]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 59909802HCID 59909802、化合物

生成物 1

HCID 59909816HCID 59909816、化合物収率 101%

実験手順

tert-Butyl (3R)-3-{3-[(4-chlorophenoxy)methyl]-1,2,4-oxadiazol-5-yl}6-cyclohexylhexanoate (Preparation 56) (215 mg, 0.46 mmol) was treated with trifluoroacetic acid (5 ml) and the resulting mixture was stirred at room temperature under a nitrogen atmosphere for 4 hours. The solvent was removed under reduced pressure and the residue azeotroped from toluene to afford the title compound (189 mg).

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue azeotroped from toluene

出典と根拠

ORDレコード
ord-a939e69104da4b938bbd532c30cdf3c5
出典データセット
uspto-grants-2002_09
特許番号
US06448278B2

反応ノート

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