Isobutylene → chloroacetaldehyde O-tert-butyloxime

Then, 0.47 g of chloroacetoaldehyde oxime, 0.1 ml of concentrated sulflic acid, and 10 ml of diethyl ether are placed in a reaction vessel, into which isobutene gas is blown with stirring under ice cooling, and the stirring is further continued at room temperature. After completion of the reaction, the reaction mixture is slowly poured into saturated aqueous sodium hydrogencarbonate solution, and extracted twice with diethyl ether. The diethyl ether layers are combined, washed with 10% aqueous sodium hydroxide solution and water in this order, dried over anhydrous magnesium sulfate, and concentrated, which affords chloroacetoaldehyde O-tert-butyloxime.

1. customis further continued at room temperature
2. customAfter completion of the reaction
3. extractionextracted twice with diethyl ether
4. washwashed with 10% aqueous sodium hydroxide solution and water in this order
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated

ORDレコード

ord-6fe1b3a8e39f41808b795413f2455f89

出典データセット

uspto-grants-2002_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06448444B1