Hydrochloric Acid → 2-(4-ethoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic Acid

HRID 1280406ノート

反応式

HRID 1280406 の反応式
C[O:2][C:3]([C:5]1[C:6]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH3:22])=[CH:16][CH:15]=2)=[N:7][N:8]2[C:13]=1[CH:12]=[CH:11][CH:10]=[N:9]2)=[O:4].[OH-].[Na+].Cl>C(O)C>[CH2:21]([O:20][C:17]1[CH:18]=[CH:19][C:14]([C:6]2[C:5]([C:3]([OH:4])=[O:2])=[C:13]3[N:8]([N:9]=[CH:10][CH:11]=[CH:12]3)[N:7]=2)=[CH:15][CH:16]=1)[CH3:22]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 542755002-(4-ethoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic Acid Methyl Ester

生成物 1

HCID 225623382-(4-ethoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic Acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-(4-ethoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester (1.2 g), ethanol (10 ml) and 2N sodium hydroxide (10 ml) was heated to 800 for 1.5 h. The mixture was allowed to cool and acidified to pH 1 with 2N hydrochloric acid. The title compound was isolated by filtration as a brown solid (716 mg, 63%). MH+ 284.

後処理

  1. temperaturewas heated to 800 for 1.5 h
  2. temperatureto cool

出典と根拠

ORDレコード
ord-d51abc5001504f28b81093f4a08b3439
出典データセット
uspto-grants-2002_09
特許番号
US06451794B1

反応ノート

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