HCID 18425441、化合物 → [1-(2,2,2-trifluoroethyl)piperidin-4-yl]methanamine
反応式
C(O[NH:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([F:21])([F:20])[F:19])[CH2:13][CH2:12]1)C1C=CC=CC=1>C(O)C.[Pd]>[NH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([F:21])([F:19])[F:20])[CH2:13][CH2:12]1参加物
4
実験手順
4-Benzyloxyaminomethyl-1-(2,2,2-trifluoroethyl)piperidine was dissolved in ethanol (50 mL) and hydrogenated over 10% palladium on carbon (0.5 g) for 10 hours. The mixture was filtered through a pad of celite and washed with methanol. The filtrate was evaporated to give 1.17 g of 4-aminomethyl-1-(2,2,2-trifluoroethyl)piperidine as a semi-solid.
後処理
- filtrationThe mixture was filtered through a pad of celite
- washwashed with methanol
- customThe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-b7b17105a05f4e978f7d04e8abdb8dc1
- 出典データセット
- uspto-grants-2002_09
- 特許番号
- US06451804B1
反応ノート
読み込み中…