Trifluoroacetic acid → HCID 69924259、化合物

HRID 1280731ノート

反応式

HRID 1280731 の反応式
C(OC([N:8]1[CH2:12][CH2:11][C@@H:10]([S:13][C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[CH2:9]1)=O)(C)(C)C.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>C(Cl)Cl>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[NH:8]1[CH2:12][CH2:11][C@@H:10]([S:13][C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[CH2:9]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 69926446HCID 69926446、化合物

生成物 1

HCID 69924259HCID 69924259、化合物収率 109.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(R)-3-(4-Hydroxy-phenylsulfanyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (3.0 g, 10.2 mmol) in CH2Cl2 (36 ml) was treated with trifluoroacetic acid (7.8 ml, 0.1 mol). After 1 hour stirring at room temperature, the reaction mixture was concentrated to provide (R)-4-(pyrrolidin-3-yl-sulfanyl)-phenol trifluoroacetic acid (3.46 g) as an orange oil, MS: m/e=196.2 (M+H+) and [α]D20=+25.060 ° (c=1.2, MeOH).

後処理

  1. concentrationthe reaction mixture was concentrated

出典と根拠

ORDレコード
ord-0bdfbdc4bbe843059c802c12523aa161
出典データセット
uspto-grants-2002_09
特許番号
US06451819B2

反応ノート

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