Aluminium lithium hydride → HCID 15936950、化合物

HRID 1280740ノート

反応式

HRID 1280740 の反応式
[H-].[H-].[H-].[H-].[Li+].[Al+3].C[O:8][C:9](=O)[CH:10]([F:19])[CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1COCC1>[F:19][CH:10]([CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][OH:8]

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 86584023HCID 86584023、化合物

生成物 1

HCID 15936950HCID 15936950、化合物収率 99.8%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

To a 0° C. suspension of LiAlH4 (0.4 g, 10.6 mmol) in dry THF (5 ml) was added dropwise a solution of (RS)-2-fluoro-4-phenyl-butyric acid methyl ester (1 g, 5.3 mmol) in dry THF (10 ml). After 1 hour stirring at 0° C., the reaction mixture was quenched successively with H2O (0.4 ml), 5N NaOH (0.4 ml) and again H2O (1.2 ml). The resulting solid was filtered and the filtrate was concentrated to provide (RS)-2-fluoro-4-phenyl-butan-1-ol (0.89 g, 99%) as a colorless oil, MS: m/e=168.1 (M+).

後処理

  1. customthe reaction mixture was quenched successively with H2O (0.4 ml), 5N NaOH (0.4 ml) and again H2O (1.2 ml)
  2. filtrationThe resulting solid was filtered
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-9efcf73044344bba87983126c711ab7b
出典データセット
uspto-grants-2002_09
特許番号
US06451819B2

反応ノート

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