反応式
I.[CH3:2][N:3]1[CH2:8][CH2:7][N:6]([C:9](=[NH:11])[NH2:10])[CH2:5][CH2:4]1.[Na].CO[C:15]1[C:16](=O)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1>C(O)C>[CH3:2][N:3]1[CH2:8][CH2:7][N:6]([C:9]2[N:10]=[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=[C:21]3[N:11]=2)[CH2:5][CH2:4]1参加物
実験手順
4-Methyl-1-piperazinecarboximidamide hydroiodide (17.8 g) was suspended in ethanol (15 ml). Sodium (1.5 g) in ethanol (47.8 ml) was added to it. The mixture was stirred at room temperature for 30 min. A solution of 2-methoxy-2,4,6-cycloheptatrien-1-one in ethanol (12 ml) was added dropwise. The mixture was refluxed for 3 hr and evaporated. The residue was taken in water and extracted with ethyl acetate in a continuous extractor. The organic layer was dried and evaporated. The residue was chromatographed through a column of silica gel using 5% methanol in chloroform and the eluates were evaporated. The residue was taken up in diethyl ether and filtered. The precipitate was crystallized from diethyl ether-hexane to obtain the title compound (3.4 g): mp 93°-95° C.; ir (CHCl3) 1600, 1565 and 1523 cm-1 ; uv max (MeOH) 291 (ε7,280), 262(ε28,445) and 238 nm(ε23,970); nmr-(CDCl3) δ 2.3(3H,s), 2.5(4H,t), 4.0(4H,t) and 7.2-8.0(5H,m) and Anal. Calcd for C13H16N4 : C, 68.39 % H, 7.06% N, 24.54% N, 24.54% and Found: C, 68.45% H, 6.99% N, 24.27%.
後処理
- temperatureThe mixture was refluxed for 3 hr
- customevaporated
- extractionextracted with ethyl acetate in a continuous extractor
- customThe organic layer was dried
- customevaporated
- customThe residue was chromatographed through a column of silica gel using 5% methanol in chloroform
- customthe eluates were evaporated
- filtrationfiltered
- customThe precipitate was crystallized from diethyl ether-hexane
出典と根拠
- ORDレコード
- ord-b7c9e065a63b4d43a06a4f1bc4c19422
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04258188
関連ノート
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