Hydrochloric Acid → (2R,3R,4R)-3,4-Dihydroxy-2-hydroxymethyl-1-(2,3-dihydroxyprop-1-yl)pyrrolidine hydrochloride

HRID 1280808ノート

反応式

HRID 1280808 の反応式
C([O:8][C@H:9]1[C@H:13]([O:14]CC2C=CC=CC=2)[CH2:12][N:11]([CH2:22][CH:23]([OH:26])[CH2:24][OH:25])[C@@H:10]1[CH2:27][O:28]CC1C=CC=CC=1)C1C=CC=CC=1.[ClH:36]>[Pd].C(O)C>[ClH:36].[OH:8][C@H:9]1[C@H:13]([OH:14])[CH2:12][N:11]([CH2:22][CH:23]([OH:26])[CH2:24][OH:25])[C@@H:10]1[CH2:27][OH:28]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 54393635(2R,3R,4R)-3,4-dibenzyloxy-2-benzyloxymethyl-1-(2,3-dihydroxyprop-1-yl)pyrrolidine2 回

生成物 1

HCID 69965749(2R,3R,4R)-3,4-Dihydroxy-2-hydroxymethyl-1-(2,3-dihydroxyprop-1-yl)pyrrolidine hydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The title compound was synthesized as described for compound 9 using (2R,3R,4R)-3,4-dibenzyloxy-2-benzyloxymethyl-1-(2,3-dihydroxyprop-1-yl)pyrrolidine (Compound 17) (0.424 g, 0.89 mmol), ethanol (80 ml), 10% Pd/C (0.1 g), and excess of 4 M hydrochloric acid to convert the amine to the hydrochloride salt. (2R,3R,4R)-3,4-Dihydroxy-2-hydroxymethyl-1-(2,3-dihydroxyprop-1-yl)pyrrolidine hydrochloride was obtained as white crystals (0.216 g, yield: 100%) with melting point above 230° C. (decomposition).

後処理

  1. customThe title compound was synthesized

出典と根拠

ORDレコード
ord-51f2136ac9614909b6cb73db077c4d89
出典データセット
uspto-grants-2002_09
特許番号
US06451836B1

反応ノート

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