Water → 2-ethyl-1,5,6,7-tetrahydro-1-(2-phenyl-phenylmethyl)-4H-indol-4-one

HRID 1280820

反応式

HRID 1280820 の反応式
[C:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH2:13][NH2:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[CH3:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21].C([O:25][CH2:26][CH3:27])(=O)C.[C:28]1(C)C=CC=C[CH:29]=1>>[CH2:17]([C:18]1[N:14]([CH2:13][C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:21]2[CH2:28][CH2:29][CH2:27][C:26](=[O:25])[C:20]=2[CH:19]=1)[CH3:16]

参加物

5

反応物 4

HCID 962WaterHCID 1140TolueneHCID 2633661-Biphenyl-2-ylmethanamineHCID 21226206Ethyl acetate hexane

生成物 1

HCID 184261202-ethyl-1,5,6,7-tetrahydro-1-(2-phenyl-phenylmethyl)-4H-indol-4-one

実験手順

2-Phenyl-phenylmethyl amine (3 g, 0.0164 mol) and an equivalent amount of 2-(2-oxobutyl)-1,3-Cyclohexyldione were dissolved in 30 mL of toluene and heated at reflux temperature with a water separator. After several hours, solvent was stripped off and the residue subjected to flash chromatography on silica eluting with 3:1 hexane/ethyl acetate to afford 4.5 g of the subtitled compound as an oil.

後処理

  1. temperatureheated
  2. waitAfter several hours

出典と根拠

ORDレコード
ord-7ad3d50b91644ceebdde922da5394e8a
出典データセット
uspto-grants-2002_09
特許番号
US06451839B1

関連ノート

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