Sodium Hydroxide → 6-[(2-Methyl-3-pyridinyl)oxy]-3-pyridinamine
反応式
[Sn](Cl)(Cl)(Cl)Cl.[CH3:6][C:7]1[C:12]([O:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][N:15]=2)=[CH:11][CH:10]=[CH:9][N:8]=1.[OH-].[Na+]>Cl>[CH3:6][C:7]1[C:12]([O:13][C:14]2[N:15]=[CH:16][C:17]([NH2:20])=[CH:18][CH:19]=2)=[CH:11][CH:10]=[CH:9][N:8]=1参加物
5
実験手順
A solution of 14.35 g of tin chloride in 30 ml of concentrated hydrochloric acid is added to a mixture of 5 g of 2-(2-methylpyrid-3-yloxy)-5-nitropyridine and the whole is heated at reflux for 1 hour. The reaction mixture is cooled and adjusted to basic pH by the addition of concentrated sodium hydroxide solution. After the removal of a precipitate by filtration, the aqueous phase is extracted with ethyl acetate. After conventional working up, the expected product is isolated in the form of a violet powder.