化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Anhydride → 2-(p-Fluorobenzoyl)-3-ethoxycrotononitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Triethyl orthoacetate | HCID 66221 | — |
| 反応物 | p-Fluorobenzoylacetonitrile | HCID 2783172 | — |
| 生成物 | 2-(p-Fluorobenzoyl)-3-ethoxycrotononitrile | HCID 70529331 | — |
反応手順
A solution of 16.3 g. of p-fluorobenzoylacetonitrile and 18.3 ml. of triethyl orthoacetate in 35 ml. of acetic anhydride is heated on a steam bath for 2.5 hours. The solvents are removed in vacuo and the residue is distilled at 165°-167° C./300μ. Upon cooling, this distillate solidifies and is recrystallized from methylene chloride/hexane to give the desired 2-(p-fluorobenzoyl)-3-ethoxycrotononitrile, m.p. 77°/89° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04259256 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-ea48427f139844aca6b6b4feacd5221b |
| 出典メモ | uspto-grants-1981_03 |