Trifluoroacetic acid → 4-Aminonicotinic acid

HRID 1281924

反応式

HRID 1281924 の反応式
C(OC([NH:8][C:9]1[C:14]([C:15]([OH:17])=[O:16])=[CH:13][N:12]=[CH:11][CH:10]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][C:9]1[C:14]([C:15]([OH:17])=[O:16])=[CH:13][N:12]=[CH:11][CH:10]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 221726234-{[(Tert-butoxy)carbonyl]amino}pyridine-3-carboxylic acid

生成物 1

HCID 3199794-Aminonicotinic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 4-(N-t-butoxycarbonylamino)nicotinic acid (2.72 g, 11.4 mmol), TFA (10 mL), and CH2Cl2 (20 mL) is stirred at room temperature for 12 h. The volatiles are removed under reduced pressure, and the resulting crude 4-amino nicotinic acid is used directly in the next reaction.

後処理

  1. customThe volatiles are removed under reduced pressure
  2. customthe resulting crude 4-amino nicotinic acid is used directly in the next reaction

出典と根拠

ORDレコード
ord-f28ae5e3b9764bcab2804e3869caafe6
出典データセット
uspto-grants-2002_09
特許番号
US06455534B2

関連ノート

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