7-Methoxy-1-benzofuran-2-carbaldehyde → (7-Methoxy-1-benzofuran-2-yl)methanol

HRID 1282026ノート

反応式

HRID 1282026 の反応式
[BH4-].[Na+].[CH3:3][O:4][C:5]1[C:13]2[O:12][C:11]([CH:14]=[O:15])=[CH:10][C:9]=2[CH:8]=[CH:7][CH:6]=1>CO.O>[CH3:3][O:4][C:5]1[C:13]2[O:12][C:11]([CH2:14][OH:15])=[CH:10][C:9]=2[CH:8]=[CH:7][CH:6]=1

参加物

5

反応物 2

HCID 34573107-Methoxy-1-benzofuran-2-carbaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 11788606(7-Methoxy-1-benzofuran-2-yl)methanol収率 96.6%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

Sodium borohydride (0.462 g) was added in one portion to a stirred solution of 7-methoxybenzofuran-2-carbaldehyde (2.15 g) in methanol (50 ml) at room temperature and the reaction was stirred for 3 hours. The reaction mixture was then diluted with water (100 ml) and extracted with dichloromethane (3×30 ml). The organic extracts were combined, washed with water (30 ml), dried over magnesium sulphate, filtered and the solvent removed in vacuo to afford the title compound (2.10 g) as a pale orange liquid.

後処理

  1. extractionextracted with dichloromethane (3×30 ml)
  2. washwashed with water (30 ml)
  3. dry with materialdried over magnesium sulphate
  4. filtrationfiltered
  5. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-c875c35a05074203b8a8bc97b7db37d4
出典データセット
uspto-grants-2002_09
特許番号
US06455561B1

反応ノート

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