2-(Bis(2-hydroxyethyl)amino)ethanesulphonic acid → N,N-di-[2-(3,4,5-trimethoxybenzoyloxy)ethyl]taurine

HRID 128208

反応式

HRID 128208 の反応式
[OH:1][CH2:2][CH2:3][N:4]([CH2:11][CH2:12][OH:13])[CH2:5][CH2:6][S:7]([OH:10])(=[O:9])=[O:8].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH:22]=[C:23]([O:27][CH3:28])[C:24]=1[O:25][CH3:26])[C:19](Cl)=[O:20]>N1C=CC=CC=1.C(O)C>[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH:22]=[C:23]([O:27][CH3:28])[C:24]=1[O:25][CH3:26])[C:19]([O:1][CH2:2][CH2:3][N:4]([CH2:11][CH2:12][O:13][C:19](=[O:20])[C:18]1[CH:17]=[C:16]([O:15][CH3:14])[C:24]([O:25][CH3:26])=[C:23]([O:27][CH3:28])[CH:22]=1)[CH2:5][CH2:6][S:7]([OH:10])(=[O:8])=[O:9])=[O:20]

参加物

5

反応物 2

HCID 732432-(Bis(2-hydroxyethyl)amino)ethanesulphonic acidHCID 78282Benzoyl chloride, 3,4,5-trimethoxy-

生成物 1

HCID 12942415N,N-di-[2-(3,4,5-trimethoxybenzoyloxy)ethyl]taurine

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 1049Pyridine溶媒

反応条件

温度
80 °C

実験手順

8.5 G of the product obtained in Example 2 (a) was suspended in 25 ml of anhydrous pyridine, and 18.4 g of 3,4,5-trimethoxybenzoyl chloride added slowly under agitation. After being left for one hour at ambient temperature the mixture was heated to 80° C. for a further hour. It was then cooled to ambient temperature, diluted with 50 ml of ethanol and left to stand in a refrigerator. A colourless crystalline compound precipitated which milted at 174°-178° C. After recrystallisation from methanol, the melting point was 180°-183° C. The yield was 11.5 g of pure product.

後処理

  1. temperatureIt was then cooled to ambient temperature
  2. waitleft
  3. customA colourless crystalline compound precipitated which
  4. custommilted at 174°-178° C
  5. customAfter recrystallisation from methanol

出典と根拠

ORDレコード
ord-b1c815612f6b4507bd14234b027a76db
出典データセット
uspto-grants-1981_03
特許番号
US04259332

関連ノート

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