Sodium Hydroxide → 1-(4-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)phenyl)cyclopropanecarboxylic acid

HRID 1282110ノート

反応式

HRID 1282110 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]4([C:24]([O:26]C)=[O:25])[CH2:23][CH2:22]4)=[CH:17][CH:16]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]4([C:24]([OH:26])=[O:25])[CH2:22][CH2:23]4)=[CH:17][CH:16]=3)[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 18422997Methyl 1-(4-((4-(4-fluorophenyl)piperazin-1-yl)methyl)phenyl)cyclopropanecarboxylate

生成物 1

HCID 184230631-(4-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)phenyl)cyclopropanecarboxylic acid収率 79.6%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

Methyl 1-(4-((4-(4-fluorophenyl)piperazin-1-yl)methyl)phenyl)cyclopropanecarboxylate (2.26 g) was dissolved in ethanol (18 ml) and a solution of sodium hydroxide (0.49 g) in water (4.6 ml) was added, and the mixture was heated at 70° C. for 2 hr. The solvent was evaporated, and the residue was dissolved in water (200 ml). The solution was neutralized with hydrochloric acid and extracted with ethyl acetate (300 ml). The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound (1.73 g) as white crystals, m.p.=74-77° C.

後処理

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in water (200 ml)
  3. extractionextracted with ethyl acetate (300 ml)
  4. washThe extract was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-415e75cc841c440cbd4cbe244e0f570c
出典データセット
uspto-grants-2002_09
特許番号
US06455528B1

反応ノート

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