Hydrochloric Acid → 2-Methyl-2-(4-methylphenyl)propanoic acid
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:12])([CH3:11])[C:9]#N)=[CH:4][CH:3]=1.[OH-:13].[Na+].C(O)C[O:17]CCO.Cl>O>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:12])([CH3:11])[C:9]([OH:17])=[O:13])=[CH:4][CH:3]=1参加物
6
実験手順
A solution of 2-(4-methylphenyl)-2-methylpropionitrile (53.61 g), sodium hydroxide (40.4 g), diethylene glycol (160.8 ml) and water (60.6 ml) was refluxed for 18 hr. The reaction mixture was poured into water (3000 ml) and conc. hydrochloric acid (90 ml) was added. The generated crystals were collected by filtration to give the title compound (60.0 g) as pale-brown crystals, m.p.=78-81° C.
後処理
- additionwas added
- filtrationThe generated crystals were collected by filtration
出典と根拠
- ORDレコード
- ord-0636ae7279c74635a7af00ce486818ba
- 出典データセット
- uspto-grants-2002_09
- 特許番号
- US06455528B1
反応ノート
読み込み中…