Water → N-(1-(4-hydroxymethylphenyl)-1-methylethyl)acetamide
反応式
[C:1]([NH:4][C:5]([C:8]1[CH:17]=[CH:16][C:11]([C:12](OC)=[O:13])=[CH:10][CH:9]=1)([CH3:7])[CH3:6])(=[O:3])[CH3:2].[BH4-].[Li+].O>O1CCCC1>[OH:13][CH2:12][C:11]1[CH:10]=[CH:9][C:8]([C:5]([NH:4][C:1](=[O:3])[CH3:2])([CH3:7])[CH3:6])=[CH:17][CH:16]=1参加物
5
実験手順
To a solution of methyl 4-(1-acetamido-1-methylethyl)benzoate (37.14g) in tetrahydrofuran (370 ml) was added lithium borohydride (6.88 g) and the mixture was refluxed for 19 hr. The reaction mixture was poured into water (1000 ml) and extracted with ethyl acetate (1000 ml). The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated and the obtained residue was recrystallized from ethyl acetate to give the title compound (18.24 m.p.=126-129° C.
後処理
- temperaturethe mixture was refluxed for 19 hr
- extractionextracted with ethyl acetate (1000 ml)
- washThe extract was washed with saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent was evaporated
- customthe obtained residue was recrystallized from ethyl acetate
出典と根拠
- ORDレコード
- ord-eca1881ab8af41a0a27c81f76b283411
- 出典データセット
- uspto-grants-2002_09
- 特許番号
- US06455528B1
反応ノート
読み込み中…