Water → 4-Methoxy-2-(piperazin-1-yl)pyrimidine

HRID 1282167ノート

反応式

HRID 1282167 の反応式
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.O>C(#N)C>[CH3:9][O:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[N:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 4837PiperazineHCID 5889352-Chloro-4-methoxypyrimidine

生成物 1

HCID 114809874-Methoxy-2-(piperazin-1-yl)pyrimidine収率 90%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A suspension of 2-chloro-4-methoxypyrimidine (21.5 g) and piperazine (64.0 g) in acetonitrile (200 ml) was refluxed for 30 min. The reaction mixture was poured into water (500 ml) and extracted with chloroform (400 ml). The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound (26.0 g) as a pale-yellow oil.

後処理

  1. temperaturewas refluxed for 30 min
  2. extractionextracted with chloroform (400 ml)
  3. washThe extract was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-5c2dcbca42a644a7b85acf3e1349d051
出典データセット
uspto-grants-2002_09
特許番号
US06455528B1

反応ノート

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