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Boc-D-Tyr(Bzl)-Oh → Boc-(D)-Tyr-Pro p-cyanobenzylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Boc-D-Tyr(Bzl)-Oh | HCID 6992575 | — |
| 反応物 | Boc-(D)-Tyr(Bzl)-Pro p-cyanobenzylamide | HCID 131723502 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Palladium | HCID 23938 | — |
| 生成物 | Boc-(D)-Tyr-Pro p-cyanobenzylamide | HCID 131723501 | — |
反応手順
12.5 g of Boc-(D)-Tyr(Bzl)OH were converted as in Example 3 into 18.9 g of Boc-(D)-Tyr(Bzl)-Pro-p-cyanobenzylamide, dissolved in 780 ml of MeOH and hydrogenated with Pd/C at room temperature. After 6 h, the catalyst was filtered off and the solvent was stripped off. Boc-(D)-Tyr-Pro-p-cyanobenzylamide was obtained in quantitative yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06455671B1 |
| 出典データセット | uspto-grants-2002_09 |
| ORD ID | ord-07ed3033b6b14ef797fc17a296793ec0 |
| 出典メモ | uspto-grants-2002_09 |