HRID1282278

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N[C@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O

HCID6992575

未命名化合物

结构：CC(C)(C)OC(=O)N[C@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N1CCC[C@H]1C(=O)O.N#Cc1ccc(C[NH-])cc1

HCID131723502

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)O.N#Cc1ccc(C[NH-])cc1

HCID131723501

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID23938

Palladium

PROCEDURE

实验过程

12.5 g of Boc-(D)-Tyr(Bzl)OH were converted as in Example 3 into 18.9 g of Boc-(D)-Tyr(Bzl)-Pro-p-cyanobenzylamide, dissolved in 780 ml of MeOH and hydrogenated with Pd/C at room temperature. After 6 h, the catalyst was filtered off and the solvent was stripped off. Boc-(D)-Tyr-Pro-p-cyanobenzylamide was obtained in quantitative yield.

WORKUP

后处理

filtrationthe catalyst was filtered off

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-07ed3033b6b14ef797fc17a296793ec0
来源数据集: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06455671B1
来源说明: uspto-grants-2002_09

反应 SMILES

N(C(OC(C)(C)C)=O)[C@@H](C(O)=O)CC1C=CC(OCC2C=CC=CC=2)=CC=1.[NH:28]([C:55]([O:57][C:58]([CH3:61])([CH3:60])[CH3:59])=[O:56])[C@@H:29]([C:45]([N:47]1[CH2:54][CH2:53][CH2:52][C@H:48]1[C:49]([OH:51])=[O:50])=[O:46])[CH2:30][C:31]1[CH:36]=[CH:35][C:34]([O:37]CC2C=CC=CC=2)=[CH:33][CH:32]=1.[C:62]([C:64]1[CH:71]=[CH:70][C:67]([CH2:68][NH-:69])=[CH:66][CH:65]=1)#[N:63]>CO.[Pd]>[NH:28]([C:55]([O:57][C:58]([CH3:61])([CH3:60])[CH3:59])=[O:56])[C@@H:29]([C:45]([N:47]1[CH2:54][CH2:53][CH2:52][C@H:48]1[C:49]([OH:51])=[O:50])=[O:46])[CH2:30][C:31]1[CH:32]=[CH:33][C:34]([OH:37])=[CH:35][CH:36]=1.[C:62]([C:64]1[CH:71]=[CH:70][C:67]([CH2:68][NH-:69])=[CH:66][CH:65]=1)#[N:63]