Sodium Hydroxide → 1,4-Dimethyl-5-(p-fluorobenzoyl)-pyrrole-2-acetic acid

HRID 1282369ノート

反応式

HRID 1282369 の反応式
[CH3:1][N:2]1[C:6]([C:7](=[O:15])[C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[C:5]([CH3:16])[CH:4]=[C:3]1[CH2:17][C:18]([O:20]CC)=[O:19].[OH-].[Na+]>>[CH3:1][N:2]1[C:6]([C:7](=[O:15])[C:8]2[CH:9]=[CH:10][C:11]([F:14])=[CH:12][CH:13]=2)=[C:5]([CH3:16])[CH:4]=[C:3]1[CH2:17][C:18]([OH:20])=[O:19]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 18424154HCID 18424154、化合物

生成物 1

HCID 185443041,4-Dimethyl-5-(p-fluorobenzoyl)-pyrrole-2-acetic acid収率 91%

実験手順

A suspension of 3.03 g. (0.01 mole) of ethyl 1,4-dimethyl-5-(p-fluorobenzoyl)-pyrrole-2-acetate in 11 ml. of 1N sodium hyroxide solution is heated under reflux for 30 minutes. The solution is filtered while hot and acidified with dilute hydrochloric acid. The precipitate is collected, air dried and recrystallized from 2-propanol to give about 2.5 g. (91% yield) of 1,4-dimethyl-5-(p-fluorobenzoyl)-pyrrole-2-acetic acid as a white solid, m.p. 176-178° C.

後処理

  1. additionA suspension of 3.03 g
  2. temperatureunder reflux for 30 minutes
  3. filtrationThe solution is filtered while hot and
  4. customThe precipitate is collected
  5. customair dried
  6. customrecrystallized from 2-propanol
  7. customto give about 2.5 g

出典と根拠

ORDレコード
ord-e2b2495adc7f4e25a5ad40e940376a48
出典データセット
uspto-grants-2002_09
特許番号
US06455703B2

反応ノート

読み込み中…