4-(Methylsulfonyl)benzaldehyde → 2-Methoxymethyl-6-methyl-4-(4'-methylsulphonylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

HRID 1283289

反応式

HRID 1283289 の反応式
[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH2:13]([O:15][C:16](=[O:23])[CH2:17][C:18]([CH2:20][O:21][CH3:22])=O)[CH3:14].[CH2:24]([O:26][C:27](=[O:32])/[CH:28]=[C:29](\[NH2:31])/[CH3:30])[CH3:25]>C(O)C>[CH2:13]([O:15][C:16]([C:17]1[CH:9]([C:8]2[CH:11]=[CH:12][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:6][CH:7]=2)[C:28]([C:27]([O:26][CH2:24][CH3:25])=[O:32])=[C:29]([CH3:30])[NH:31][C:18]=1[CH2:20][O:21][CH3:22])=[O:23])[CH3:14]

参加物

5

反応物 3

HCID 2203764-(Methylsulfonyl)benzaldehydeHCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 12645099Ethyl 4-methoxy-3-oxobutanoate

生成物 1

HCID 681210172-Methoxymethyl-6-methyl-4-(4'-methylsulphonylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester収率 65%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 9.2 g of 4-methylsulphonylbenzaldehyde, 8 g of γ-methoxyacetoacetic acid ethyl ester and 6.5 g of β-aminocrotonic acid ethyl ester in 40 ml of ethanol is heated to the boil and, after cooling, 2-methoxymethyl-6-methyl-4-(4'-methylsulphonylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained in the form of yellow crystals of melting point 156°-158°C.

後処理

  1. temperatureafter cooling

出典と根拠

ORDレコード
ord-c4a94212307643d4a19a8927daeaaf68
出典データセット
uspto-grants-1976_08
特許番号
US03974278

関連ノート

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